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Digitale Medien

Investigation of the thermal isomerization of 1α,25-dihydroxycholecalciferolGeneric name is calcitriol. by nuclear magnetic resonance spectroscopy (1983)

Grant, Anne ; Bhattacharyya, Pranab K.

New York, NY : Wiley-Blackwell

International Journal of Chemical Kinetics 15 (1983), S. 381-395

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Details

ISSN: 0538-8066

Schlagwort(e): Chemistry ; Physical Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: This investigation of the kinetics and thermodynamics of the thermal isomerization reaction of 1α,25-dihydroxycholecalciferol, the physiologically active metabolite of vitamin D3, is based on the simultaneous determinations of 1α,25-(OH)2D3 and its previtamin analog by nuclear magnetic resonance spectroscopy which distinguishes these compounds from possible impurities. The kinetics at different temperatures are used to obtain the activation parameters for the sigmatropic [1,7] thermal interconversion process which is shown to be compatible with a reaction that is unimolecular and concerted. The nature of the transition state of the activated complex, the reaction energetics, and the relative stabilities of 1α,25-(OH)2D3 and vitamin D3 are discussed.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/kin.550150405

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