ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Attempts to cyclize the p-nitrophenyl esters of the pentapeptides L-valyl-L-(Nδ-tosyl)-ornithyl-L-leucyl-D-phenylalanyl-L-proline and L-valyl-L-(Nε-tosyl)-lysyl-L-leucyl-D-phenylalanyl-L-proline lead to a condensation and cyclization reaction of 2 molecules each of activated esters. The cyclic products are identical with those obtained from the corresponding derivatives of the linear decapeptides.This kind of doubling reaction during cyclization seems to play a greater role in the synthesis of homodetic cyclo-polypeptides than anticipated. The phenomenon might be expected to occur especially well with peptides containing an odd number of amino acid residues.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19580410727