ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis of so-called rac.-corpaverine (I) has been achieved. Reaction of the methobromide VI and 4-methoxybenzylmagnesium chloride gave the S-benzyloxytrimethoxy-substituted derivative VII, which was catalytically debenzylated to the corresponding 8-hydroxy derivative I. The latter has been related by O-methylation to the known tetramethoxy-substituted 1,2,3,4-tetrahydroisoquinoline VIII. Physical-chemical data for I are in full agreement with the structure. The melting points of the free base and its hydrochloride, however, differ considerably from those recently published by KAMETANI et al. [3] [4] for so-called corpaverine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19660490608
