ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
To prove the chemical structure of metabolites of the antidepressant drug (dimetacrin2) (Istonil®3), 2- and 3-hydroxy-9,9-dimethyl-10-dimethylaminopropyl-acridane and 2-hydroxy-monometacrin4 were synthesized using substituted alkoxy diphenylamines (V) as intermediates. The methoxy compounds on treatment with strong acids cyclized either to the corresponding acridanes or to their O-demethylated derivatives, VI (X = OCH3 or OH), depending on concentration and temperature.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19690520207