ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Antitumor showdomycin analoguesA series of 3-glycosylidenesuccinimides (3) and 3-glycosylidene-1-phenyl-succinimides (5) have been prepared in good yields using a Wittig reaction. In each case, the preponderant, or even the exclusive, isomer formed was E. As expected from orbital considerations, the contribution to the conformational equilibrium of the rotamer whose H—C (γ) and H—C(δ) bonds were antiparallel was low. One of these succinimide derivatives 3a showed interesting anticancer activity, similar to that of the sugar enone C. These compounds probably act as somewhat selective alkylating agents.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19790620408