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  • 1
    Electronic Resource
    Electronic Resource
    Un nouvel exemple de nucléoside à sucre ramifié insaturé: la désoxy-3′-méthylidène-3′-adénosine (1981)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 64 (1981), S. 425-429 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A Novel Example of Unsaturated Branched-chain Sugar Nucleoside: 3′-Deoxy-3′-methylidene-adenosineStarting from 5-O-benzoyl-3-C-methylidene-3-deoxy-1,2-O-isopropylidene-α-D-erythro-pentofuranose (11) the title compound 8 has been prepared. Its α-anomer (9) and the acyclic sugar nucleoside 10 have been obtained as by-products. Adenosine deaminase slowly deaminated 8, 9 being not affected. Compound 8 exhibited no antiviral activity, whereas one of its saturated analogues (13) inhibited the multiplication of the herpes-1 (HF) virus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19810640207
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