ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Nucleotides, XVII. Synthesis of Homogeneous Adenosyl-3′,5′-oligomers by the Phosphotriester MethodThe chemical synthesis of the fully protected trimer 12, the tetramers 11 and 23 as well as the pentamer 14 was achieved in preparative scales starting from the fully blocked adenosine-3′-phosphotriesters 1, 2, and N6-benzoyl-2′,3′-bis-O-(tert-butyldimethylsilyl)adenosine (6). All intermediates and end products have been isolated, purified and characterized by elemental analyses, UV, and CD spectra. Deprotection of the various blocking groups proceeds without difficulties to afford the free trimeric, tetrameric, and pentameric oligoadenylates 15, 16, and 24 in high yields.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19830660713