ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The molecular structure of pyroergotamine has been determined by single-crystal X-ray diffraction analysis to be the pyruvoyldiketopiperazine 1. The diketopiperazine ring exists in a folded or boat conformation, with a dihedral angle of 40° between the two almost planar peptide units. The R-group of the phenylalanine residue occupies a quasi-axial position of the diketopiperazine ring, while that of the proline residue is in a quasi-equatorial position. Puzzling spectroscopic and chemical properties of the compound can be rationalised in terms of crowding within the molecule.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19850680322
