ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A novel, mild, and highly stereoselective transformation of epoxides to azidohydrins by treatment with Et3Al/HN3 in toluene is described. As an example for the versatility of the reaction, a polyfunctional compound, 14,15-epoxy-14,15-dihydromilbemycin D (1), was transformed to 14-azido-14,15-dihydro-15-hydroxymilbemycin D (2) in 61% yield.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19860690222