ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The four protected diastereoisomcrs 7a/7b and 8a/8b P-thioadenylyl-(3′-5′)-P-thioadenylyI-(3′-5′)-adenosine were synthesized, separated, and deblocked to the free oligonucleotides (Scheme). Biochemical characterization of these (3′-5′)phosphorothioate analogues of adenyiate trimer indicate that these compounds, and the corresponding 5′-monophosphates, neither bind to nor activate RNase L, and are considered to be valuable control compounds in screening experiments.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19910740420