ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Macrocyclic Imides: Versatile Synthons in Ring-Enlargement ReactionsMacrocyclic imides differ from phthal- or succinimids in their increased electrophilicity. This property makes them versatile synthons for reactions with several nucleophiles. If a nucleophile is attached to the N-substituent of the imide, an intramolecular reaction will occur leading to ring-enlarged products. Use of N, O, and C nucleophiles for this synthetic pathway is reported. Synthetic transformations of e.g. cyclododecanone leads to 17-, 18-, or 19-membered macrolides, 11, 12, 15, 16, 21, 27, 30, in three to five steps.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19940770321
