ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Cyclo(-D-Leu-L-MeLeu-D-Leu-L-MeLeu-D-Leu-L-MeLeu-) (1) and cyclo(-L-Leu-D-Leu-L-MeLeu-D-Leu-L-Leu-D-Leu-) (2) were synthesized and used for a study of the interaction of β -rings in solution. In appropriate solvents, 1 and 2 formed dimers consisting of two β -rings connected through six interannular H-bonds and having the N -Me group(s) on the solvent-exposed face. The study also afforded indications that 2 formed different dimers of this kind, differing in the relative orientation of the two β -rings. These experimental observations provide strong support to the idea that unsubstituted D,L-alternating cyclooligopeptides, such as cyclo(hexaleucine), can self-assemble and give rise to long tubular stacks of β -rings.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19940770607
