ISSN:
0020-7608
Keywords:
Chemistry
;
Theoretical, Physical and Computational Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A physical model of an oxidation-reduction reaction for immobilized enzyme is considered. The influence of the electric-field intensity of a biological membrane on the enzyme reaction rate is analyzed. It is shown that the low-frequency dipole-active vibration of the oppostite charge groups of the substrate and enzyme relative to each other leads to multiquantum excitation of the system over the conformational degree of freedom. This excitation provides an abrupt increasing of the tunnel decay rate of the substrate-enzyme complex on a free product and a free enzyme. This way of the reaction is more probable in comparison with the usual overbarrier process. Some consequences for the immobilized cytochrome P-450 are discussed. © 1998 John Wiley & Sons, Inc. Int J Quant Chem 66: 255-260, 1998
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
