ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The condensation of phenyl-, p-tolyl-, p-anisyl-, and p-chlorophenyl isopropyl ketones with dimethyl methylsuccinate in the presence of potassium t-butoxide, gave the crystalline (E)-4-aryl-3-methoxycarbonyl-2-methyl-4-isopropyl-but-3-enoic acidsi.e., Ar and COOCH3 in trans-position. The nomenclature of cis/trans isomers used herein follows the IUPAC 1968 Tentative Rules, Section E, Fundamental Stereochemistry, J. org. Chemistry 35, 2849 (1970). See also: J. E. BLACKWOOD, C. L. GLADYS, K. L. LOENING, A. E. PETRARCA and J. E. RUSH, J. Amer. chem. Soc. 90, 510 (1968); Introduction to Subject Index of Chem. Abstr. 66 (1963). 1 as major products. These esters resisted oxidation, and the position of the double bond was indicated by their infrared absorption, as well as that of some derived products. Their configuration followed from their conversion to the 4-acetoxy-2-naphthoates 2. The condensation also gave oily half-ester fractions which proved to contain small amounts of the (Z)-isomers 5 by their conversion (in low yields) to the oxoindenyl acids 6.
Additional Material:
9 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19713130502
