ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Partial Syntheses of Cardenolides and Cardenolide Analogues. III. Synthesis of Cardenolide-Analogous Methyl β-Steroidyl-crotonatesStarting with 14-hydroxy-5β, 14β-pregnan-3β-yl-acetate (2) the synthesis of the cardenolide analogues methyl 3β-acetoxy-14, 15β-epoxy-24-nor-5β, 14β-chol-20(22)-en-23-oate (7) via Reformatskij synthesis and methyl 3β, 14-dihydroxy-5β, 14β-chol-20(22)-en-23-oate (11) via addition of lithium ethoxyacetylide to 2 are described.The activity of 11 in the ATPase-test is about the same as that of digitoxigenin.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19803220619