ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Determination of Configurations by the Aid of Sterically Corresponding Epoxides. X. Glycidic Nitriles. III Synthesis of 4α-Aryl-2-methyl-1α-oxaspiro(2.5)octane-2-nitrilesThe condensation of 2-aryl-cyclohexanones 1a--d with α-chloropropionitrile at 80° in presence of NaH and in dimethoxyethane yields the corresponding glycidic nitriles. The configuration and the conformation of the C-2-isomeric 4α-aryl-2-methyl-1α-oxaspiro[2.5]octane-2-nitriles 3b--e have been analysed. The ratio of the resulting C-2-isomeric glycidic nitriles has been determined.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19833250516