ISSN:
0021-8383
Schlagwort(e):
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
2, 2-Disubstituted Cyclopentane-1, 3-diones. IV. Synthesis of Prochiral Intermediates for the Synthesis of 8-Methyl-prostaglandin C2 by Alkylation of 2-Methyl-cyclopentane-1, 3-dione with 1-Bromo-alk-2-ynes.2-Methyl-cyclopentane-1, 3-dione (1) is preferentially C-alkylated by 1-bromo-alk-2-ynes in aqueous sodium hydroxide solution. By this method it is possible to prepare 2,2-disubstituted-1, 3-diones (3-8), which can be converted into prochiral intermediates for 8-methyl-PGC2, containing the complete carboxylic side chain.
Zusätzliches Material:
2 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/prac.19843260311