ISSN:
0899-0042
Keywords:
enantiomers
;
warfarin
;
phenprocoumon
;
complexes
;
HPLC
;
fluorescent enhancement
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The fluorescences of warfarin and phenprocoumon are enhanced following complexation with β-cyclodextrin; (+)-(R)- and (-)-(S)-phenprocoumons have different affinities for this cyclodextrin, whereas the corresponding enantiomers of warfarin have similar binding constants. Apparently, hemiketal formation in the case of warfarin minimizes chiral discrimination. This is confirmed using a β-cyclodextrin bonded chromatography column on which the phenprocoumon enantiomers are separated, whereas those of warfarin are not.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.530030208
