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Digitale Medien

Separation of the enantiomers of coumarinic anticoagulant drugs by capillary electrophoresis using maltodextrins as chiral modifiers (1994)

D'Hulst, Annick ; Verbeke, Norbert

New York, NY [u.a.] : Wiley-Blackwell

Chirality 6 (1994), S. 225-229

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Details

ISSN: 0899-0042

Schlagwort(e): warfarin ; phenprocoumon ; CE ; chiral ; maltooligosaccharides ; enantiomeric excess ; assay ; Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The separation and quantitation of coumarinic anticoagulant drug enantiomers were achieved by direct chiral capillary electrophoresis using complex maltooligosaccharide mixtures as stereoselective electrolyte modifiers. Chiral separations were characterized by a high selectivity and efficiency, enabling enantiomeric excess determinations. In addition, preliminary results indicate the applicability of the method for the determination of individual enantiomers in biological samples. So the method can be used to perform stereoselective pharmacokinetic studies. © 1994 Wiley-Liss, Inc.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/chir.530060403

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