ISSN:
0899-0042
Schlagwort(e):
successive optical resolution
;
replacing crystallization
;
threonine
;
optically active cosolute
;
L-serine
;
4-hydroxy-L-proline
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
DL-Threonine [DL-Thr; (2RS,3SR)-2-amino-3-hydroxybutanoic acid] was optically resolved by replacing crystallization using L-serine (L-Ser) and 4-hydroxy-L-proline (L-Hyp) as optically active cosolutes. D-Thr was allowed to crystallize preferentially from racemic aqueous solutions in the presence of these L-α-amino acids. The optical resolution of DL-Thr was more successfully achieved by using L-Ser, whose structure is more similar to that of DL-Thr than L-Hyp, and successively gave D- and L-Thr of 87 - 92% optical purities. The D- and L-Thr obtained were then recrystallized from water to give optically pure D- and L-Thr. © 1994 Wiley-Liss, Inc.
Zusätzliches Material:
1 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/chir.530060809
