ISSN:
0025-116X
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
The coupling reaction of ampicillin with the polysaccharide xanthane in DMSO, using dicyclohexylcarbodiimide as activator, was studied. To find the conditions for maximum yield a regression equation was established, describing the dependence of the yield of coupling product on the reaction parameters (drug/support mole ratio, activator/support mole ratio and duration), starting from an experimental, centrated rotable complex, second order program. The coupling product was spectroscopically characterized and the in vitro release rate of ampicillin in a weakly basic medium was established along with the determination of its antimicrobiological activity.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/macp.1988.021890110
