ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract N τ-methylhistamine concentrations in plasma and urine were determined using a newly developed simultaneous determination for histamine andN τ-methylhistamine, based on isotope dilution mass fragmentography. Three groups of patients were investigated: patients receiving intravenously-administered iodamide for excretory urography, patients receiving a wasp-sting challenge, and patients treated with an intravenously-administered muscle relaxant. In all patients showing a distinct systemic anaphylactic or anaphylactoid reaction histamine andN τ-methylhistamine concentrations were found to be elevated. From the results of this study it can be concluded thatN τ-methylhistamine in plasma and urine is a good parameter for histamine release, and that the determination of this histamine metabolite are less hampered by possible artefacts (due to basophil disrupture, a very short half-life time or bacterial production) than determinations of histamine itself.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01983105
