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Action of the SP2–11 and SP3–11 fragments of substance P on rat peritoneal mast cells (1987)

Piotrowski, W. ; Mead, M. ; Foreman, J. C.

Springer

Inflammation research 20 (1987), S. 178-180

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ISSN: 1420-908X

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The ability of the SP fragments SP2–11 and SP3–11 to release histamine from rat peritoneal mast cells has been compared with that of the whole peptide. SP1–11 was found to be about 3.4 times more active than SP2–11 and about 10.4 times more active than SP3–11. The substance P antagonist [D-Pro4, D-Trp7,9,10] SP4–11 was equally effective at antagonizing the histamine releasing action of SP1–11, SP2–11 and SP3–11. Benzalkonium chloride was found to be a competitive antagonist of SP and SP3–11: the dissociation constants for the benzalkonium chloride-receptor interaction being about the same when either SP1–11 or SP3–11 was used as the agonist.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02074662

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