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Cytotoxic drugs in an avian urate microcrystal arthritis (1973)

Floersheim, George L. ; Brune, Kay ; Seiler, Karl

Springer

Inflammation research 3 (1973), S. 24-27

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ISSN: 1420-908X

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The effect of single doses of cytotoxic drugs on the acute arthritis elicited by the injection of microcrystalline sodium urate into one intertarsal joint of pigeons or chickens was functionally assessed. Procarbazine and actinomycin D were effective while no inhibition was provided by cyclophosphamide, methotrexate, cytosine arabinoside, 6-mercaptopurine, vinblastine, vincristine and BCNU. It is suggested that within the anti-inflammatory repertoire displayed by antiproliferative agents, distinctive properties leading to particular interference with cellular performance might be exploited for selected therapeutic indications.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02023847

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