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Cocarcinogens of the diterpene ester type fromCroton flavens L. and esophageal cancer in Curaçao (1978)

Weber, J. ; Hecker, E.

Springer

Cellular and molecular life sciences 34 (1978), S. 679-682

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ISSN: 1420-9071

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary From the roots ofCroton flavens L., 3 highly irritant and tumor promoting Croton factorsF 1–F 3 and the corresponding 3 cryptic Croton factorsF′1–F′3 were isolated and characterized as novel esters of 16-hydroxy- and 4-deoxy-16-hydroxyphorbol, respectively. These findings suggest that tumor promoters of the phorbol ester type, ingested through the widespread and frequent use ofCroton flavens according to local habits, may be causally related to the well recognized high rate of esophageal cancer on Curaçao.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01947253

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