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Influence of substance P and fragments on passive avoidance behavior (1984)

Gaffori, O. ; Stewart, J. M. ; Wied, D.

Springer

Cellular and molecular life sciences 40 (1984), S. 89-91

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ISSN: 1420-9071

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary N-terminal and C-terminal fragments of substance P (SP) have been shown to exert opposite effects on antinociception, grooming and fighting in mice. The present experiments explored whether these findings could be generalized to passive avoidance behavior. Substance P (SP-(1-11)) and the c-terminal, fragment pyroglutamyl-SP-(7-11) attenuated passive avoidance behavior when picogram amounts were injected into the nucleus accumbens. In contrast, the N-terminal fragment, SP-(1-7) had an opposite effect and facilitated passive avoidance behavior.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01959118

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