ISSN:
1420-9071
Keywords:
Vitaceae
;
Vitis coignetiae
;
hepatoprotective substance
;
oligostilbene
;
hepatotoxin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The methanol extract of the Oriental medicinal plantVitis coignetiae (Vitaceae) showed hepatoprotective activity in the in vitro assay method using primary cultured rat hepatocytes. Activity-guided fractionation of the extract afforded ɛ-viniferin as an active principle. The protective effect of ɛ-viniferin against mice carbon tetrachloride-induced hepatic injury in mice was shown by serum enzyme assay as well as by pathological examination. In addition to ɛ-viniferin, plant oligostilbenes, ampelopsins A, C, F and the mixture of vitisin A andcis-vitisin A were also present in the extract. Among them, ampelopsin C and the mixture of vitisin A andcis-vitisin A were found to be powerful hepatotoxins.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01964921