ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract 3,3-Dimethyloxaziridine reacts with chloral and acetaldehyde to give crystalline N-(α-hydroxyalkyl)oxaziridines; the reaction with acetaldehyde is reversible. The N-aminomethylation of NH-oxaziridines is not realized, evidently because of the tendency of oxaziridines to iminate nucleophiles. The weakly nucleophilic chloromethylphthalimide and chloromethyl methyl ether give imidomethyl- and methoxymethyloxaziridines. 3,3-Dimethyldiaziridine reacts with excess chloromethyl methyl ether to give the N-monomethoxymethyl derivative. It is shown that α-hydroxyalkyloxaziridines and methoxymethyl-substituted oxaziridine and dizaridine do not enter into the aminomethylation of compounds with a labile hydrogen.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00475333
