ISSN:
1573-1111
Keywords:
Helicates
;
dynamic combinatorial chemistry
;
molecular diversity
;
templating
;
metallo-supramolecular chemistry
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Molecular diversity can easily be generated in metallo-supramolecular systems by simple mixing of oligodentate ligands and appropriate metal ions. In this reaction either a defined coordination compound is formed in a selective self-assembly process or a mixture is obtained. Depending on the system such a mixture can possess a statistical distribution of components or the formation of some species is thermodynamically favored leading to only a few out of several possible compounds (or in the extreme to only one). Simple well-defined mixtures containing only a few components or pure supramolecular aggregates can be generated from sequential or directional ligands, from mixtures of ligands and/or metals, and by introducing templates which support the formation of defined metallo-supramolecular aggregates. In the latter case it is possible first to generate a mixture of components which are in dynamic equilibrium (dynamic combinatorial library). In a second step, a template can be added, which in a dynamic process transforms such a library into one well-defined species. Thus, the initial generation of molecular diversity allows in a subsequent selection step in an evolutionary process the formation of the most favored receptor/substrate adduct (``dynamic combinatorial chemistry'').
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008066616875
