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Differentiation of Burkitt Lymphoma cells by Hexamethylenbisacetamide (1988)

Semmel, M. ; Hanania, N. ; Huet, S. ; [et al.]

Springer

Molecular biology reports 13 (1988), S. 151-157

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ISSN: 1573-4978

Keywords: HMBA ; Burkitts Lymphoma ; c-myc ; tyrosine phosphorylation

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Hexamethylenbisacetamide (HMBA) can induce the Burkitt lymphoma Raji cells to enter the differentiation process as evidenced by the decrease of HLA-DR antigens. This event is preceded by a decrease of c-myc expression and of the phosphorylation of cellular proteins, due toeither a decrease of tyrosine protein kinase activity or an increase of tyrosine phosphatase activity. These three events form a sequence and are part of the genetic program for differentiation and growth though they may not be causally related.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00444311

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