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Ideas in Theoretical Biology Origin of Cancerous Cells from Tumours (1998)

Niu, Deng K. ; Chen, Jia-Kuan

Springer

Acta biotheoretica 46 (1998), S. 379-381

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ISSN: 1572-8358

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract With a previous paper (Niu & Wang, 1995), a general, hypothetical outline of the mechanism of carcinogenesis was proposed. With reference to the fact of starvation-induced hypermutation in micro-organisms, we propose that the hypoxia commonly seen in the cells at the centre of solid tumours might also result in hypermutation, and then p53-dependent programmed cell death. Like the apparently adaptive mutations in micro-organisms, only those genes (e.g. p53) that enable the cells to escape from apoptosis may be selected.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1001803420183

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