ISSN:
1572-901X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The coupling of radionuclides such as copper (67Cu and 64Cu) to antibodies by bifunctional chelating agents (or BCA) requires extremely high stability to avoid in vivo release of metal. Six copper(II) and five nickel(II) complexes with N2S2 tetradentate ligands were synthesised for potential medical applications, and stability studies were conducted. I.r and u.v.-vis. spectra provided structural data on the geometry of the complexes. The redox potentials obtained from cyclic voltammetry allowed us to estimate the stability constants of each complex and then select the more suitable ligand for future applications in radioimmunotherapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1006939403074