ISSN:
1573-7446
Keywords:
anthelmintic
;
buffalo
;
dosage
;
efficacy
;
fasciolosis
;
metabolites
;
pharmacokinetics
;
triclabendazole
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A study was conducted on the pharmacokinetics and therapeutic efficacy of triclabendazole at three low dose rates of 0.5, 1.0 and 1.5 mg/kg body weight in buffaloes experimentally infected with Fasciola gigantica. The pharmacokinetics were compared with the effects of a single intraruminal dose at 24.0 mg/kg body weight in uninfected buffaloes. At all three dose rates, an equilibrium between the absorption of triclabendazole and the disposition of its metabolites was observed by days 3 and 4 and remained almost unchanged thereafter. Continuous daily dosing at 1.5 mg/kg body weight proved to be efficacious against liver fluke infection in buffaloes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00419183
