ISSN:
1573-8221
Keywords:
GABA-uptake
;
synaptosomes
;
psychotropic drugs
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of phenothiazine neuroleptics (chlorpromazine, trifluoperazine, perphenazine, fluophenazine and antidepressants (imipramine and fluacizine) on the uptake of GABA-H3 by synaptosomes of the rat cerebral cortex was studied. All the neuroleptics proved to be active inhibitors of the accumulation of neuromediator by the synaptosomes. The antidepressants were less active. The most active inhibitor of GABA uptake was chlorpromazine and the least active was the new Soviet phenothiazine antidepressant fluacizine. It is suggested that their effect on GABA uptake may play a role in the mechanism of the synaptic action of neuroleptics.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00786424
