ISSN:
1573-8221
Keywords:
pyrimethamine
;
pregnancy
;
decidual tissue
;
induced teratogenesis
;
embryonic death
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The dynamics of the histopathological changes in albino rat embryos following administration of single teratogenic doses of pyrimethamine on the ninth day of pregnancy was investigated. The most sensitive structure to the action of pyrimethamine was found to be the decidual tissue, the first disturbances in which were observed as early as 1 h after treatment. The cells of the various germ layers reacted differently to pyrimethamine. The cytotoxic effect of the compound was particularly marked on the embryonic mesoderm and the extraembryonic ectoderm. It is concluded that hemodynamic disorders connected with disturbance of the decidual tissue play an essential role in the mechanism of the harmful action of some chemical teratogens on mammalian embryos.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00803027
