ISSN:
1573-8221
Keywords:
DNA
;
transformation
;
oncogenic activity
;
restriction endonucleases
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Transforming and oncogenic activity of whole Simian adenovirus SA 7 DNA (Ad SA 7) and of a mixture of its fragments produced by restriction endonucleases R. Bam HI and R. Sal I, was studied. Whole virus DNA was shown to transform rat kidney cells and rat embryonic fibroblasts and to induce tumor formation in newborn hamsters. Ad SA 7 DNA, hydrolyzed by R. Bam HI, possesses transforming activity; a mixture of DNA fragments produced by R. Sal I was oncogenic for hamsters.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00830359