ISSN:
1573-3297
Keywords:
Taste genetics
;
congenic
;
mouse
;
bitter taste
;
sucrose octaacetate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Psychology
Notes:
Abstract Sensitivity to the bitter acetylated sugar sucrose octaacetate (SOA) is mediated by a single-locus system with three alleles in mice. Inbred strains are classified according to SOA phenotype as tasters, nontasters, or demitasters (intermediate sensitivity). A congenic quartet created from taster and nontaster strains has been used to investigate the effect of theSoa locus on non-SOA aspects of taste sensitivity. In this study, we created a third congenic set, C3.SW-Soa a, from taster (SWR/J) and demitaster (C3HeB/FeJ) strains. After 11 lineal backcross generations these C3.SW mice carry the tasting allele on a 99% C3 demitaster background. After testing a total of 938 mice, taster-demitaster proportions across 12 generations were consistent with expectations from a monogenic model. The resultant three-strain congenic series will allow further examination of the mechanisms of taste.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02197181
