ISSN:
1573-7217
Keywords:
antiestrogen
;
athymic mice
;
drug metabolism
;
DMBA-induced tumors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Toremifene is a nonsteroidal antiestrogen currently being evaluated for the treatment of breast cancer. Toremifene (10−10-10−6 M) inhibited the growth of MCF-7 breast cancer cellsin vitro but was ineffective against hormone-independent MDA-MB-231 cells. This activity was reproducedin vivo using the athymic mouse model. Maximal MCF-7 tumor growth was produced in athymic mice by circulating estradiol levels of approximately 200 pg/ml (from a 0.5 cm silastic capsule implanted sc). Toremifene (77 ± 44 µg/day from a 2 cm silastic capsule) inhibited estradiol (0.5 cm capsule)-stimulated growth by more than 70%. No tumor growth was observed in mice treated with toremifene alone, although toremifene acted as a weak partial agonist and potent antagonist on the mouse uterus. The growth of MDA-MB-231 tumors was not influenced by either estradiol or toremifene. Toremifene (200 µg/day) was effective in preventing the development of 7,12-dimethylbenzanthracene-induced rat mammary tumors when given po from day 28 after carcinogen administration. The antitumor activity was reversed if the toremifene was stopped. These findings indicate toremifene is a tumoristatic agent rather than a tumoricidal agent. Clinical trials with toremifene should employ an indefinite treatment strategy to control tumor recurrence in adjuvant studies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01807139