ISSN:
1573-7217
Keywords:
breast cancer
;
prognosis
;
epidermal growth factor receptor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A retrospective study was performed on 109 human breast tumors stored in liquid nitrogen in order to assess the prognostic value of epidermal growth factor receptor (EGF-R) (median patient follow-up 5 years). A significant inverse relationship was observed between EGF-R and both estrogen (ER) and progesterone receptors (PR). Univariate analysis showed a trend towards a shorter metastasis-free survival both in the overall population and in node-negative patients with EGF-R positive tumors. Multivariate analysis of the overall population showed that lymph-node involvement and PR status were the only significant variables in predicting metastasis-free survival. However, in patients receiving no adjuvant treatment (hormone therapy or chemotherapy), EGF was the only significant variable in the multivariate Cox analysis. No c-erbB-1 amplification was detected in these tumors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01806288
