ISSN:
1573-7217
Keywords:
breast cancer
;
p53 gene
;
p53 protein
;
prognosis
;
therapy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Alterations of the p53 tumor suppressor gene are the most common genetic changes found so far in breast cancer, suggesting that the gene plays a central role in the development of the disease. p53 functions as a negative regulator of cell growth, and alterations in the gene lead to loss of this negative growth regulation and more rapid cell proliferation. A number of independent groups using different methods of detection have shown that p53 alterations are associated with more aggressive tumor biologic factors and a poorer prognosis in breast cancer patients. Because of its possible role in the regulation of apoptosis and response to DNA damage, p53 status could also be a predictive marker for response to hormonal or chemotherapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00666204
