ISSN:
1573-7217
Keywords:
estrogen receptor
;
breast cancer
;
EGF receptor
;
growth factors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01806484