ISSN:
1573-2568
Keywords:
portal hypertensive gastropathy
;
laser Doppler flowmetry
;
propranolol
;
gastrin
;
pepsinogen I
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Gastric mucosal hyperemia associated with elevated serum gastrin level has been suggested in cirrhotic patients with portal hypertensive gastropathy (PHG). Clinical evidence has shown that these patients may benefit from propranolol administration. The aim of this study was to investigate effect of propranolol on gastric mucosal perfusion and serum gastrin level in cirrhotic patients with portal hypertensive gastropathy. Gastric mucosal perfusion was assessed by laser Doppler flowmetry. Measurements were performed under basal conditions and after observer-blind administration of propranolol (30–60 mg/day,N=9) or placebo (N=9) for seven days. Placebo had no effect on either gastric mucosal perfusion or serum gastrin level. In contrast, propranolol administration significantly decreased both antrum gastric mucosal perfusion (from 0.88±0.28 to 0.73±0.26 V,P〈0.05) and corpus gastric mucosal perfusion (from 0.94±0.35 to 0.78±0.25 V,P〈0.05). However, this drug had no effect on serum gastrin level. We conclude that chronic propranolol administration in cirrhotic patients with portal hypertensive gastropathy may reduce gastric mucosal perfusion without changing serum gastrin level.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02087662