ISSN:
1573-8744
Keywords:
mean residence time
;
statistical moments
;
pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The present communication seeks to end a controversy created by a recent publication regarding the applicability of statistical moment principles for determination of mean residence time of drug in the body ¯tb.It is shown that the equation ¯tb=AUMC/AUC iscorrect when applied to pharmacokinetic systems in which the total drug elimination rate is directly proportional to the drug concentration in the systemic circulation, i.e., firstorder central elimination. More general equations for ¯tb in terms of elimination rate, amount eliminated, and amount in the body are presented along with demonstrations of their utility.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01059336
