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Statistical estimations in pharmacokinetics (1974)

Boxenbaum, Harold G. ; Riegelman, Sidney ; Elashoff, Robert M.

Springer

Journal of pharmacokinetics and pharmacodynamics 2 (1974), S. 123-148

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ISSN: 1573-8744

Keywords: pharmacokinetics ; computer program ; NONLIN ; data weighting ; isoniazid

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract Several important statistical aspects of pharmacokinetic analyses by digital computer are discussed. These include selection of appropriate equations, weighting of data, precision of parameter estimates, comparisons of parameters, analysis of weighted residuals, and criteria useful in the selection of particular models. Data obtained after administration of isoniazid and isonicotinuric acid to man are analyzed to illustrate the usefulness of the discussed methods.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01061504

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