ISSN:
1573-8744
Keywords:
pharmacokinetics
;
nonlinear regression
;
curve fitting
;
computer program
;
time sharing
;
modeling
;
weighting
;
least squares
;
parameter estimation
;
discrimination between models
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The problems of curve fitting and modeling in pharmacokinetics are discussed. A new nonlinear regression program FUNFIT, written for interactive time sharing, is presented which should be more reliable than programs based on the Gauss-Newton or other related gradient methods. The new program and the well-established program NONLIN were tested on two linear models using human plasma drug level data. FUNFIT found a substantially better solution than NONLIN in the majority of the cases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01061732
