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Mathematical prediction of drug distributionin vivo: Studies with doxantrazole in rats (1978)

Caldwell, Ian C. ; Mahmood, Saiyed ; Weatherall, Miles

Springer

Journal of pharmacokinetics and pharmacodynamics 6 (1978), S. 521-537

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ISSN: 1573-8744

Keywords: compartmental analysis ; doxantrazole ; drug distribution ; mathematical prediction ; pharmacokinetics ; rat

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract A pharmacokinetic model incorporating 14 compartments and 29 transfer coefficients has been developed from experimental data obtained after intravenous administration of a single dose to describe the distribution of doxantrazole in the rat. The distribution calculated from the model agreed closely with that determined experimentally. In addition, the model was able to predict with considerable accuracy the distribution of doxantrazole after repeated dosing.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01062107

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