ISSN:
1573-4919
Keywords:
cultured vascular smooth muscle cells
;
protein tyrosine kinases
;
proliferation
;
protein tyrosine phosphorylation
;
smooth muscle contraction
;
signal transduction
;
vasoactive peptides
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Protein tyrosine phosphorylation is believed to play a central role in signaling pathways initiated by growth factor receptor activation. Recent studies have shown that various vasoactive peptides, in addition to eliciting a contractile response, also serve as growth factors for vascular smooth muscle and stimulate tyrosyl phosphorylation of several endogenous proteins. Some of these proteins have been identified and are similar to those stimulated by growth factor receptor activation. Furthermore, evidence is also accumulating to support an involvement of protein tyrosine phosphorylation, in acute action of groth factors and vasoactive peptides on smooth muscle contractility. This review will briefly summarize the recent work on vasoactive peptide-mediated protein tyrosine phosphorylation in cardiovascular tissues and its potential functional significance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01076567
