ISSN:
1573-7365
Keywords:
antagonist
;
benzodiazepine
;
hepatic encephalopathy
;
coma
;
γ-aminobutyric acid (GABA)-ergic
;
neural binding
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The progressive course of hepatic encephalopathy developing in rats after massive hepatic ischemia due to hepatic artery ligation within 48 hr of a portacaval shunt was not altered by the injection of a benzodiazepine antagonist, CGS 8216, in a dose that was sufficient to reverse diazepam-induced coma quickly. The onset of hepatic coma was shortened 20 to 25% by the antagonist, rather than being delayed, as would be expected if hepatic coma were due to a γ-aminobutyric acid (GABA)-ergic effect. The neural binding of GABA by brains from rats in deep hepatic coma was unaffected by the injection of the benzodiazepine antagonist.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00999611