ISSN:
1573-904X
Keywords:
G protein coupled receptors
;
neurotransmitter receptors
;
hormone receptors
;
adrenergic receptors
;
muscarinic cholinergic receptors
;
second messengers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The G protein coupled receptors (GPC-Rs) comprise a large superfamily of genes encoding numerous receptors which all show common structural features, e.g., seven putative membrane spanning domains. Their biological functions are extremely diverse, ranging from vision and olfaction to neuronal and endocrine signaling. The GPC-Rs couple via multiple G proteins to a growing number of recognized second messenger pathway, e.g., cAMP and phosphatidyl inositol turnover. This review summarizes our current knowledge of the molecular mechanisms by which the GPC-Rs activate second messenger systems, and it addresses their regulation and structure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015969301407
