ISSN:
1608-3245
Keywords:
HIV-1
;
integration
;
oligonucleotide
;
quadruplex
;
triplex-forming oligonucleotide
;
parallel duplex
;
phosphorothioate oligonucleotide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Oligonucleotide inhibitors of the HIV-1 DNA integration identified to date are reviewed. Two basic strategies of blocking the integration are considered: shielding the integrase-binding sites on the viral DNA by triplex-forming oligonucleotides, and directly inhibiting the enzyme with oligonucleotide agents.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026631910681